Preheat oven to 400°F (200°C) and prepare a clean workspace.

In a bowl, mix ground chicken, breadcrumbs, eggs, garlic powder, and onion powder until well combined.

Shape the mixture into palm-sized patties, slightly thicker in the center.

Place patties on a lined baking sheet and bake for 20-25 minutes until golden brown and cooked through (internal temp of 165°F).

Mix ketchup and mayonnaise for the sauce; add optional hot sauce for extra flavor.

Assemble burgers on buns with sauce and desired toppings.